You have questions about Afrezza, we have answers. Below are answers to some frequently asked questions (FAQ). However, only your healthcare professional can help you decide if Afrezza is right for you.
Afrezza is inhaled at the beginning of a meal. After you inhale Afrezza, the insulin passes quickly through your lungs and into your bloodstream where it begins reducing blood sugars.
Afrezza is unique because it is the only inhaled insulin available. It starts working quickly without the need for needles. Once you breathe Afrezza into your lungs using the inhaler, insulin appears in your bloodstream within 1 minute1 and it starts to work within about 12 minutes.2
Afrezza has been proven to help control blood sugar levels in both type 1 and type 2 diabetes. If your diabetes medications are not giving you the control you need, adding Afrezza may help control the blood sugar spikes that happen when you eat. Afrezza does not replace treatment with long acting insulin.
If you have type 1 diabetes, you will still need to take a long-acting insulin. Your health care professional may prescribe Afrezza to treat mealtime spikes in blood sugar. If you are living with type 2 diabetes, your healthcare provider may consider adjustments to your other diabetes medications if they prescribe Afrezza.
Afrezza can be taken with oral diabetes medicines. Be sure to tell your healthcare professional about all other medicines and supplements you are taking because they can affect the way your insulin works.
Afrezza is a rapid acting insulin used to control blood sugar in adults with diabetes. It is not for people with certain types of lung disease (such as asthma or COPD) or who smoke. Do not use Afrezza if you are allergic to regular human insulin or any of the ingredients in Afrezza. Afrezza is not for children under 18 years of age. Consult with your healthcare provider to determine if Afrezza is right for you.
The most common side effects of Afrezza include low blood sugar (hypoglycemia), cough and sore throat or irritation.
Before prescribing Afrezza, your healthcare professional will perform an FEV1 breathing test to establish a baseline reading of your lung function. Your healthcare provider may test again at 6 months and once a year after that. The test measures how much air you breathe in and out, how long it takes for you to exhale completely, and is used to monitor your lung function over time.
Take Afrezza exactly as your healthcare provider tells you to. Your healthcare provider should tell you how much Afrezza to use and when to use it. Read the detailed Instructions for Use that comes with your Afrezza.
A small amount of powder residue in the mouthpiece or cartridge is normal. This does not affect your dose.
Do not wash the Afrezza inhaler. You can wipe the mouthpiece with a clean, dry cloth to remove moisture or lipstick.
Checking your blood sugar levels around mealtime, and keeping track of the levels, helps you and your healthcare professional monitor your progress over time and determine how well your treatment plan is working. Talk to your healthcare provider about what your blood sugar goal should be and when you should check your blood sugar levels.
Download our blood sugar log and use it to track your levels.
Afrezza contains insulin. Hypoglycemia is the most common side effect with any insulin product. Severe hypoglycemia can cause seizures, may be life-threatening, or cause death. Talk to your healthcare provider to learn how to recognize the signs and symptoms of hypoglycemia and create an action plan in case of an episode of hypoglycemia. Signs and symptoms that may indicate low blood sugar include: dizziness or light-headedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood change, hunger.
In studies, cough was reported in about 27% of patients using Afrezza; 2.8% of patients gave cough as a reason for stopping Afrezza. Talk to your healthcare professional if you develop a persistent or recurring cough or breathing difficulties while taking Afrezza.
Afrezza is available on 70% of private insurance plans with an average out-of-pocket cost of approximately $45 per month. If your doctor recommends Afrezza for you, call your insurance provider to check whether Afrezza is covered. You may also be able to save on your prescriptions with an Afrezza Patient Savings Card. Restrictions may apply. Please contact us at 1-844-3-AFREZZA if you have questions about insurance coverage.
 Data on File
 Afrezza® Prescribing Information. MannKind Corporation.
Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.
Afrezza can cause serious side effects, including: Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD).
Afrezza can cause serious side effects, including:
Sudden lung problems (bronchospasms). Do not use Afrezza if you have long-term (chronic) lung problems such as asthma or chronic obstructive pulmonary disease (COPD). Before starting Afrezza, your healthcare provider will give you a breathing test to check how your lungs are working.
Do not use Afrezza if you:
Before using Afrezza, tell your healthcare provider about all your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins or herbal supplements.
Before you start using Afrezza, talk to your healthcare provider about low blood sugar and how to manage it.
While using Afrezza do not:
Afrezza may cause serious side effects that can lead to death, including:
See “What is the most important information I should know about Afrezza?” at the top of this page.
Treatment with TZDs and Afrezza may need to be changed or stopped by your healthcare provider if you have new or worse heart failure.
Get emergency medical help if you have:
• Trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.
The most common side effects of Afrezza include:
These are not all the possible side effects of Afrezza. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 (1-800-332-1088).
Active ingredient: human insulin
Inactive ingredients: fumaryl diketopiperazine, polysorbate 80
General information about the safe and effective use of Afrezza.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Afrezza for a condition for which it was not prescribed. Do not give Afrezza to other people, even if they have the same symptoms that you have. It may harm them.
This Medication Guide summarizes the most important information about Afrezza. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Afrezza that is written for health professionals.